![]() ![]() Initially, it was reported that taurineĭeficiency leads to retinal degeneration in cats ( 3). ![]() Since 1975, the implication of taurine in homeostasis has intrigued The currently used name (taurine) first appeared in the literature Named taurus, after the Latin Bos taurus which means Ox. Known taurine originating from Ox bile and they named it In 1827, the German professors Friedrich TiedemannĪnd Leopold Gmelin became the pioneers who isolated the currently In the future, further clinical studies are required to support the ameliorative effect of taurine against oxidative stress. Apart from the results derived from research findings, the current review bridges the gap between bench and bedside, providing mechanistic insights into the biological activity of taurine that supports its potential therapeutic efficacy in clinic. In parallel, the synergistic effect of taurine with other potential therapeutic modalities in multiple disorders are highlighted. Taurine is regarded as a cytoprotective molecule due to its ability to sustain normal electron transport chain, maintain glutathione stores, upregulate anti‑oxidant responses, increase membrane stability, eliminate inflammation and prevent calcium accumulation. The present review gives a comprehensive description of all the underlying mechanisms of taurine, with the aim to explain its anti‑oxidant actions. The development of hypertension, muscle/neuro‑associated disorders, hepatic cirrhosis, cardiac dysfunction and ischemia/reperfusion are examples of some injuries that are linked with oxidative stress. Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress.
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